Glass plate negatives are made from a silver halide emulsion poured onto a glass support, then exposed and developed to produce a high-resolution photographic image. They were the dominant photographic medium from approximately 1851 (the wet collodion process) through the 1920s, and continued in scientific and professional use until the 1950s. If your family has glass plates, they're almost certainly the oldest photographs you own.
The first failure mode is mechanical: glass breaks. Glass plates are heavy (a single 5×7" plate weighs approximately 100 grams), brittle, and concentrate stress at the edges when stacked. Most surviving collections have at least a few plates with chips, cracks, or complete breaks. A broken plate isn't necessarily lost — we can often scan the fragments and digitally reassemble them — but each break represents permanent physical damage to a unique historical artefact.
The second failure mode is emulsion separation. The silver halide emulsion was bonded to glass using gelatin, which slowly degrades over a century. The result is "frilling" — the emulsion lifts away from the glass surface in flakes, taking the image with it. Once frilling starts, it accelerates with handling. Plates stored in humid conditions are particularly prone.
The third failure mode is silver tarnish. The metallic silver image slowly oxidises in air, especially when exposed to sulphur compounds. The result is the characteristic mirror-like surface ("silver mirroring") that makes glass plates look reflective at certain angles. Severe tarnishing obscures the image and is essentially irreversible without restoration.
The fourth problem is that early "wet plate" collodion negatives (1851-1880s) sometimes used chemicals that have continued to degrade over the past century in ways the original photographers couldn't have predicted. Some of these plates are now extremely fragile.